Not my usual territory but I've been following the big cat reports in the UK for years - specifically the Beast of Sherwood stuff practically on my doorstep - so I do keep an eye on similar patterns elsewhere.
What strikes me about the Ohio River corridor reports is how consistent the size descriptions are. That's actually unusual. Most mystery animal sightings are all over the place because people are terrible witnesses, but when you get multiple unconnected people saying roughly the same thing about an animal's dimensions, that's worth paying attention to.
My honest take though? Probably escaped or released exotic pets before anything more exotic than that. The US has shocking regulation around big cat ownership compared to here. Doesn't make the sightings fake, just makes the explanation more mundane than people want it to be.
Anyone got a decent map of the sighting clusters? I'd want to see if they follow the river corridor or if thats just how the reports have been framed.