Interesting thread but I'll be honest this feels more like a wildlife corridor problem than anything cryptozoological. Pumas have been expanding their range eastward for years and the trail runs through some serious remote terrain where dispersing males could go undetected for a long time.
That said I'm curious what the actual sightings are describing. Are we talking tracks, visual sightings, or both? Because if people are reporting animals significantly larger than a confirmed mountain lion that changes the conversation a bit.
I mostly follow the black-eyed children and abduction cases but I've started paying attention to cryptid animal reports more lately because the witness testimony patterns are surprisingly similar in terms of how people describe the encounter aftermath - that dissociated feeling, the sense of being watched before the sighting etc.
Anyone cross-referencing these with the BFRO database? Some of those trail corridors get a lot of overlap between big cat and Bigfoot reports which is either meaningful or just a coincidence of remote habitat.