Never been to Remington specifically but the east wing thing doesn't surprise me at all. Older asylums almost always have one section that just hits different, and it's rarely the obvious spots like operating theatres or solitary confinement blocks. The east wing placement is interesting too - in a lot of these older institutional builds the east side was used for the more "difficult" patients, partly practical reasons around morning light supposedly calming agitation, but also because it was furthest from the main entrance and administrative areas. Out of sight, basically.
What kind of off are we talking? Visual stuff, audio, just a general feeling? I've done a fair few spirit box sessions in similar locations across the UK and you do get these zones where the responses cluster, like the box just gets busier in certain rooms for no obvious reason. Would be genuinely curious whether you picked anything up on any equipment or if it was purely experiential. Also how recent was your visit - some of these places change significantly after any kind of renovation work kicks up activity.